Have you heard of CBGA? It’s making waves in the world of cannabinoids — and for a good reason! This compound is considered one of the most important components found within cannabis, as it acts as an essential building block for many other compounds.
In this blog post, we’ll be taking a closer look at what makes CBGA isolate so special and why its presence can profoundly affect cannabis plants. From its potential medicinal benefits to how it interacts with other compounds, there’s no doubt that CBGA is worth your attention.
So let’s deeply dive into understanding what makes this cannabinoid tick — and why you should know about it!
What is CBGA?
CBGA stands for Cannabigerolic acid, a non-psychoactive cannabinoid that serves as the precursor to many of the other cannabinoids we find in cannabis. CBGA is the first cannabinoid to form in the plant’s trichomes in the flowering stage, which occurs 3-4 weeks after the vegetative stage.
The CBGA acts as a sort of “mother” molecule from which several other molecules are derived.
These derivatives include two of the most well-known cannabinoids, THC and CBD, and their acidic forms, THCA and CBDA, respectively. This occurs after the CBGA undergoes decarboxylation, essentially when it’s heated and loses its carboxylic acid group.
This means that the occurrence of CBGA in a cannabis plant can significantly affect the ratio of other cannabinoids that are formed. For instance, if there is more CBGA present in the plant, there will likely be higher concentrations of THC or CBD as well.
However, since CBGA is broken down after exposure to UV light or extreme heat, it is not present in high concentrations in the finished product. Actually, between 7-8 weeks of flowering, you will find that the CBGA levels have dropped significantly, and its derivatives (THC, CBD, etc.) are now predominant.
Although CBGA isn’t present in large amounts after the decarboxylation process, scientists have discovered that this cannabinoid is among those with the most medicinal potential.
The endocannabinoid system — responsible for regulating many of the body’s natural functions — appears to respond positively to CBGA. This has led to the scientists’ increased interest in this compound and the development of strategies for isolating CBGA from other cannabinoids.
History of CBGA Isolate
Before scientists paid attention to CBGA, CBG(cannabigerol) was the main focus. This cannabinoid — a direct derivative of CBGA — was the first to be isolated from cannabis plants. This was over 50 years ago.
Israeli researchers, including Raphael Mechoulam and Yechiel Gaoni, were the first to isolate CBG in 1964 successfully. About 30 years later, Japanese scientists isolated and identified another cannabinoid, CBGA.
They revealed CBGA to be the precursor to CBG, as well as all other cannabinoids in the plant.
This discovery has sparked many new studies of the compound but particularly on the compound’s use in obtaining sustainable amounts of THCA. Engineering yeast strains as the key component for cannabinoid biosynthesis has revolutionized the industry of cannabinoid production.
This is the process through which CBGA is converted to THCA. The process requires a combination of yeast and enzymes, which act as catalysts that make the conversion possible.
So it is safe to say that CBGA isolate has been a game-changer for the cannabis industry — and we haven’t seen the last of it yet!
As a non-psychoactive cannabinoid, CBGA isolate will not produce any euphoric or sedative effects. In fact, research suggests that the presence of CBGA may even reduce the psychoactive potential of cannabis by inhibiting the formation of other cannabinoids like THC.
It is also believed to lower stress levels and promote relaxation. This could be due to its interaction with the body’s endocannabinoid system, which maintains homeostasis.
Potential Medical Benefits of CBGA
CBGA is showing great potential in both medicinal and therapeutic applications. Studies conducted suggest that this compound can be beneficial in treating a wide array of diseases, including:
Inflammatory diseases cause pain or swelling in certain parts of the body. They can range from mild to severe, and they are often chronic.
CBGA is believed to interact with the body’s endocannabinoid system, which helps regulate inflammation. Therefore, CBGA has been studied for its potential in treating Crohn’s disease and ulcerative colitis.
Colon cancer is the third most common cancer in the United States and has a high mortality rate. Based on the research on the cytotoxic effects of CBGA, the cannabinoid could be potentially used in treating colon cancer.
One of the main cytotoxic effects includes the destruction of cancer cells. This may occur by arresting the cancer cells’ cycle or directly inducing apoptosis (cell death).
Metabolism in the body is controlled by Peroxisome Proliferator-Activated Receptor (PPAR). This receptor is found in different organs, including the liver and kidney.
When this receptor can no longer regulate metabolism, metabolic diseases like diabetes can occur.
In a 2019 silicon study, a computer simulation was done to analyze the interaction of CBGA with PPAR. Results showed that CBGA can potentially treat metabolic diseases by activating PPAR.
The cardiovascular system is responsible for regulating blood pressure and ensuring that the heart works properly. High blood pressure can lead to hypertensive diseases like stroke, arteriosclerosis, etc.
Based on trials carried out on animals, CBGA was found to reduce blood pressure and act as a vasodilator. This can help protect the heart against hypertension, stroke, and other cardiovascular diseases.
Moreover, the anti-inflammatory effects of CBGA could also be beneficial in treating conditions like atherosclerosis.
CBGA is an interesting cannabinoid that is quickly gaining the attention of many researchers and scientists. Its potential in treating various diseases, such as inflammatory disease, colon cancer, metabolic disorders and heart health issues, highlights its significance.
Although many studies still need to be conducted before CBGA can be utilized to its full potential, this compound is showing great promise. With new advances in cannabinoid science, the possibilities of what CBGA isolate may offer are endless!
As cultivation technology and agricultural processes evolve, so will our understanding of cannabinoids like CBGA. From more sustainable ways to produce cannabinoid products to better extraction methods and innovative delivery systems, we can only expect that this compound will continue to make waves in the cannabis industry for years to come.
So stay tuned — the future of CBGA is looking bright!